MELATONIN - MITOCHONDRIAL SUPPORT

Often called “the sleep hormone,” melatonin is widely misunderstood. It’s often dismissed as a quick fix for sleep issues or lumped in with hormone therapies. But the truth is, melatonin is much more than a sleep aid. It’s a master antioxidant with profound effects on mitochondrial health, immune function, and overall longevity.

Before we dive into the details, let’s bust some of the biggest myths about melatonin:

MYTH #1: MELATONIN IS PRIMARILY PRODUCED BY THE PINEAL GLAND

Contrary to popular belief, only 5% of the body’s melatonin comes from the pineal gland. The vast majority, 95%, is synthesized by the mitochondria in every cell, where it plays a crucial role in cellular energy production and protection. Unlike pineal melatonin, mitochondrial melatonin is not controlled by the light-dark cycle.

MYTH #2: TAKING MELATONIN SUPPLEMENTS REDUCES NATURAL PRODUCTION

The opposite is true. Supplementing with melatonin has been shown to increase endogenous production. This happens because melatonin reactivates the pyruvate dehydrogenase complex, which is essential for producing acetyl-CoA, a key substrate for melatonin synthesis.

MYTH #3: MELATONIN IS JUST A SLEEP REGULATOR

While melatonin does help regulate circadian rhythm, its functions go far beyond sleep. Melatonin:

🛡 Scavenges free radicals and protects against oxidative stress

⚡ Boosts ATP production, enhancing mitochondrial energy output

🍽 Supports glucose metabolism and insulin regulation

🔋 Maintains mitochondrial membrane integrity, reducing cellular aging

🦠 Modulates immune function, helping the body combat inflammation and disease

By age 15-20, melatonin levels plummet by 80%, and the decline continues throughout life. This decline, combined with chronic exposure to blue light at night and electromagnetic radiation (EMFs), may be a major driver of modern diseases.

MELATONIN & MITOCHONDRIAL INTEGRITY

Melatonin levels inside mitochondria are 100 times higher than in the bloodstream. Mitochondria, our cellular powerhouses, generate reactive oxygen species (ROS) as a byproduct of energy production. Melatonin is one of the primary compounds used by mitochondria to neutralize these free radicals, preventing oxidative damage and ensuring optimal cellular function.

Melatonin and its metabolites also:

🧪 Detoxify reactive nitrogen species

❌ Limit mitochondrial-related apoptosis (cell death)

🔄 Support efficient function of the electron transport chain (ETC)

WHAT HAPPENS WHEN MELATONIN IS DEPLETED?

When the pineal gland is removed in animal studies, melatonin levels drop but only in the blood. Mitochondrial melatonin remains unchanged, further proving its independence from the pineal gland. However, research shows that animals without pineal melatonin experience accelerated oxidative damage and cellular aging.

THE TAKEAWAY

Melatonin isn’t just for sleep. It’s essential for longevity and mitochondrial health. If your goal is cellular protection, optimal energy production, and long-term vitality, melatonin supplementation may be one of the most powerful tools in your arsenal.

🌙 Supports deep, restorative sleep – Helps regulate circadian rhythms, making it easier to fall asleep and stay asleep.

🔥 Reduces inflammation – Acts as a natural anti-inflammatory agent, helping to ease chronic inflammation and support overall wellness.

🛡 Powerful antioxidant defense – Protects cells from oxidative damage by neutralizing harmful free radicals.

🧠 Enhances brain function and protection – Supports cognitive health, protects neurons from oxidative stress, and may help reduce the risk of neurodegenerative conditions.

⚡ Boosts energy and resilience to stress – Helps regulate mitochondrial function, reducing fatigue and improving the body's ability to handle stress.

💊 Take 1 capsule daily to support overall health and sleep quality.

🌙 For deeper sleep and relaxation, take 1–2 capsules 30–60 minutes before bedtime.

⚡ For antioxidant, neuroprotective and mitochondrial support, take low dose in the morning or as recommended by your healthcare professional.

📢 Best taken alone and without food. Adjust dosage based on individual needs.

⚠️ For adults only. Consult physician if pregnant/nursing, taking medication or have a medical condition. Keep out of reach of children.

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Augmentation of indices of oxidative damage in life-long melatonin-deficient rats