NAD POWER - SUPER STRENGTH

Vitamin B3 is often overshadowed by B12, but it plays a critical role in mitochondrial energy production and overall metabolic function. While B12 is essential for nerve health and red blood cell formation, B3 directly impacts how our cells generate energy and respond to stress.

Despite its importance, B3 is frequently underdosed in multivitamins, while other nutrients that are best acquired from whole foods are often included in excessive amounts. This imbalance leaves many people unknowingly deficient in niacinamide, which can lead to fatigue, poor metabolic function, and impaired cellular repair.

HOW NIACINAMIDE SUPPORTS NAD+ LEVELS

Niacinamide is a direct precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular function. NAD+ plays a key role in over 200 enzymatic reactions, supporting everything from metabolism and mitochondrial function to immune defense and DNA repair.

The body rapidly converts niacinamide into three active forms: NAD+, NADH, and NADPH. These molecules act as cellular fuel, driving the production of adenosine triphosphate (ATP)—the body’s primary energy source. Beyond energy, NAD+ also helps stabilize DNA, regulates inflammatory responses, and protects against oxidative damage that can accelerate aging.

By ensuring an adequate supply of niacinamide, we provide our cells with the tools they need to function optimally, repair damage, and resist the effects of aging and environmental stressors.

NAD+ DECLINES WITH AGE 

NAD+ is critical for energy metabolism, but its levels decline as we age. Research shows that NAD+ drops by as much as 50% between the ages of 40 and 60, contributing to a range of age-related concerns, including fatigue, cognitive decline, weakened immune function, and slower recovery from exercise or injury.

This decline is largely due to increased cellular demand for NAD+ in response to stress, inflammation, and DNA damage. When NAD+ levels are depleted, mitochondrial function suffers, leading to lower energy production and increased oxidative stress.

Maintaining optimal NAD+ levels through niacinamide supplementation helps counteract these effects, supporting energy, cognitive function, and cellular resilience. Unlike caffeine or stimulants, which provide temporary boosts, niacinamide enhances energy production at the cellular level, making it a sustainable and effective way to combat fatigue and promote longevity.

NIACINAMIDE VS. NMN

The longevity research community has placed significant focus on NAD+ precursors like NMN (nicotinamide mononucleotide), often promoting it as a superior option for boosting NAD+ levels. However, niacinamide is just as effective, more bioavailable, and significantly more affordable.

Both niacinamide and NMN ultimately convert into NAD+ through the same pathway, meaning their end benefits are nearly identical. The main difference lies in marketing and cost, with NMN being heavily commercialized as a high-end longevity supplement despite lacking a clear advantage over niacinamide.

Niacinamide provides all the benefits of NMN, including enhanced mitochondrial function, improved cellular repair, and protection against oxidative stress, without the high price tag or unnecessary hype. It is a reliable, research-backed, and accessible solution for anyone looking to optimize their NAD+ levels and support long-term health.

🔋 Enhances Mitochondrial Energy Production – Supports ATP synthesis, fueling cellular function and overall vitality.

🧠 Promotes Brain Health – Provides neuroprotective benefits that may support cognitive function and help defend against age-related decline.

🌞 Supports Healthy Skin – Reduces pigmentation, wrinkles, and sebum production while protecting against UV damage and immune suppression.

🛡️ Acts as a Powerful Antioxidant – Helps neutralize oxidative stress and supports cellular repair.

⏳ Regulates Key Longevity Pathways – Suppresses SIRT2, which may extend lifespan, and SIRT1, which influences metabolism and stress resistance.

🍽️ Balances Metabolic Function – Inhibits the release of free fatty acids, potentially improving glucose utilization and insulin sensitivity.

🔥 Supports Inflammation Control – Decreases prostaglandin synthesis, inhibits nitric oxide, and reduces serotonin synthesis, which may help modulate stress and immune responses.

❤️ Protects Vital Organs and Tissues – Supports the health of the pancreas, nerves, and vascular system, promoting long-term wellness.

⚡ Boosts Metabolic Rate – Encourages efficient energy use and may aid in weight management.

💊 Take 1 capsule in the AM with or without food. Adjust as needed per day for enhanced support.

🥗 Pair with a balanced diet and active lifestyle to maximize mitochondrial function and overall well-being.

⚠️ For adults only. Consult physician if pregnant/nursing, taking medication or have a medical condition. Keep out of reach of children.

NAD+ and Vitamin B3: From Metabolism to Therapies

Nicotinamide and neurocognitive function

Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model

Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin

Nicotinamide restores cognition in Alzheimer's disease transgenic mice

Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia